Evidence supporting the use of: Gastrodin
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Gastrodin is a bioactive compound derived from Gastrodia elata, a traditional medicinal herb widely used in East Asia. Its primary use in modern supplements and research is related to neurological health, including support for neurotransmitter balance and function. Scientific studies, mostly preclinical (animal and in vitro), indicate that Gastrodin can modulate neurotransmitter systems such as GABAergic and glutamatergic pathways. For instance, Gastrodin has demonstrated neuroprotective effects, anticonvulsant properties, and the ability to enhance cognitive function in various animal models of neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson’s disease.

Mechanistically, Gastrodin appears to increase GABA levels and receptor expression, inhibit glutamate-induced excitotoxicity, and exert antioxidant and anti-inflammatory effects in neural tissue. Some small-scale clinical trials and case reports, primarily from China, suggest benefits in conditions like migraine, dizziness, and mild cognitive impairment, though these studies often lack rigorous controls and larger sample sizes.

Overall, while there is scientific rationale and some promising early research supporting Gastrodin’s role in neurotransmitter modulation and neuroprotection, robust, high-quality human clinical evidence remains limited. Thus, its use for supporting the "Specific Neurotransmitters" body system is scientifically plausible but not yet conclusively validated in large clinical populations.

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