Evidence supporting the use of: Glutamate
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glutamate is a key excitatory neurotransmitter in the central nervous system and plays a critical role in synaptic transmission, plasticity, learning, and memory. Its function as a neurotransmitter is well-established in neurobiology. The body synthesizes glutamate endogenously, and it acts on several types of glutamate receptors, including NMDA, AMPA, and kainate receptors, which are essential for normal brain function. Numerous scientific studies have elucidated the role of glutamate in supporting the neurotransmitter system, particularly in the context of synaptic plasticity and cognitive processes (Neurosci Lett. 2016; Nat Rev Neurosci. 2012).

However, it's important to note that while glutamate is fundamental to neurotransmitter activity, dietary glutamate (such as that found in monosodium glutamate or protein-rich foods) does not significantly cross the blood-brain barrier or directly enhance neurotransmitter function in healthy individuals. Most of the brain's glutamate is synthesized locally from glucose or glutamine. Nonetheless, disturbances in glutamate signaling are implicated in various neurological disorders, such as epilepsy, schizophrenia, and neurodegenerative diseases, further underscoring its importance in neurotransmitter systems. In summary, glutamate's role in supporting the neurotransmitter body system is scientifically validated, but supplementation is not generally used as a direct therapeutic approach due to tight regulation and potential for excitotoxicity.

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