Evidence supporting the use of: Melatonin
For the body system: Specific Neurotransmitters

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin is a hormone primarily known for regulating sleep-wake cycles, but it also plays a role in modulating certain neurotransmitters. Scientific studies show that melatonin interacts with the central nervous system by influencing the release and activity of neurotransmitters such as GABA, serotonin, and dopamine. For example, melatonin has been observed to increase GABAergic activity, which can have calming effects on the brain. It also has indirect modulatory effects on serotonin pathways, partly because serotonin is a precursor to melatonin synthesis in the pineal gland.

Melatonin’s neuroprotective properties have been investigated in the context of mood disorders and neurodegenerative diseases, with some studies suggesting benefits in conditions related to neurotransmitter dysregulation, such as depression and anxiety. However, while these findings indicate a mechanistic link between melatonin and neurotransmitter function, the clinical evidence supporting melatonin supplementation specifically for direct neurotransmitter modulation (outside of sleep-related uses) is limited and not robust. Most clinical use of melatonin remains focused on sleep disorders and circadian rhythm disturbances, rather than as a primary agent for neurotransmitter support.

In summary, scientific evidence suggests that melatonin does interact with neurotransmitter systems, but its clinical use for directly supporting neurotransmitter balance is not well-established. Thus, the evidence rating is moderate-low (2).

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