Evidence supporting the use of: N-phenylacetyl-L-Prolylglycine ethyl ester
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

N-phenylacetyl-L-Prolylglycine ethyl ester, commonly known as Noopept, is a synthetic peptide that has been investigated primarily for its cognitive-enhancing properties. Its purported mechanism of action involves modulation of neurotransmitter systems in the brain, particularly those involving glutamate and acetylcholine. Animal studies and a limited number of human trials suggest that Noopept may enhance memory and learning by increasing the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), both of which are associated with neuroplasticity and neurotransmitter regulation. Additionally, some research indicates that Noopept may have neuroprotective effects, potentially reducing oxidative stress and excitotoxicity in neuronal tissues. However, the breadth of scientific evidence remains limited. Most studies have been conducted in vitro or on animals; only a few small-scale clinical trials in humans have been published, primarily in Russia. These trials suggest potential benefits for cognitive function and support the idea that Noopept modulates neurotransmitter systems, but the results are preliminary and not widely replicated. Regulatory bodies such as the FDA have not approved Noopept for any medical use, and its safety profile in long-term human use is not fully established. Thus, while there is some scientific rationale for its use to support neurotransmitter-related functions, the overall evidence is modest and insufficient for strong clinical endorsement.

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Other body systems supported by N-phenylacetyl-L-Prolylglycine ethyl ester

Brain
Dopamine
GABA
Nerves
Specific Neurotransmitters

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