Evidence supporting the use of: Panax Ginseng
For the body system: Specific Neurotransmitters

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Panax ginseng is traditionally used in Asian medicine as a general tonic for health, but in recent decades, scientific research has explored its effects on neurotransmitter systems. Several studies indicate that Panax ginseng and its active ginsenosides may influence neurotransmitter activity in the brain, particularly relating to acetylcholine, dopamine, norepinephrine, and serotonin. Preclinical research (in vitro and animal studies) has shown that ginseng extracts can modulate the release and uptake of these neurotransmitters, potentially enhancing cognitive function and mood. For example, ginsenosides have been reported to increase dopamine and serotonin levels in certain brain regions, which may underlie observed antidepressant-like and neuroprotective effects.

Some small-scale human studies suggest improvements in cognitive performance and mood with ginseng supplementation, but findings are mixed and often limited by methodological weaknesses. A few clinical trials have observed benefits in mental performance, fatigue, and subjective well-being; however, robust evidence for specific neurotransmitter effects in humans is lacking. Overall, while there is moderate scientific support from laboratory and early clinical research that Panax ginseng can support neurotransmitter-related body systems, conclusive large-scale human trials are still needed to confirm these effects and clarify mechanisms.

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