Evidence supporting the use of: Phosphatidylserine
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain and is crucial for maintaining cellular function, especially in neurons. Scientific interest in PS focuses on its potential to support cognitive functions, including memory, attention, and processing speed. PS is thought to influence neurotransmitter systems, particularly acetylcholine, dopamine, and norepinephrine, by supporting membrane fluidity and facilitating neurotransmitter release. Several clinical studies have evaluated PS supplementation in relation to cognitive decline and memory impairment, with some showing modest improvements in memory and mental function in elderly individuals with cognitive deficits. For example, a 2010 review in Journal of Clinical Biochemistry and Nutrition summarized that PS supplementation can improve memory, especially in those with age-related cognitive decline, potentially by modulating neurotransmitter activity. However, while there is evidence for effects on cognitive function, direct studies specifically linking PS supplementation to neurotransmitter levels or dynamics in humans are limited. The overall quality of evidence is moderate, with some positive human trials but also several studies showing mixed or inconclusive results. There is also a lack of large-scale, long-term randomized controlled trials. In summary, the use of phosphatidylserine to support the neurotransmitter system is scientifically justified, but the supporting evidence is moderate rather than robust.

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