Phosphatidylserine (PS) is a phospholipid component found in high concentrations in the brain and is involved in cellular function, particularly within neuronal membranes. Its use as a supplement to support neurotransmitter function and the "Specific Neurotransmitters" body system has some scientific basis. Several clinical studies suggest that PS supplementation may support cognitive functions such as memory, attention, and mental processing, particularly in elderly populations or those experiencing cognitive decline.

Phosphatidylserine appears to influence neurotransmitter systems, including acetylcholine, dopamine, and norepinephrine, by supporting membrane fluidity and facilitating neurotransmitter release and receptor function. Some small-scale human trials and animal studies have demonstrated improvements in cognitive markers with PS supplementation, although the effect sizes are generally modest. The strongest evidence exists for age-associated memory impairment, with less robust data supporting its use in younger, healthy individuals.

Overall, while there is a plausible scientific rationale and some supportive clinical data for PS in supporting neurotransmitter-related functions, the evidence is not uniformly strong or comprehensive. Larger, well-controlled studies are needed to fully validate its use for this purpose. Nevertheless, the current body of evidence justifies a moderate rating for its role in supporting the neurotransmitter system.