Evidence supporting the use of: Polygala
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Polygala, particularly Polygala tenuifolia (commonly known as Yuan Zhi or Chinese Senega), has a long history of use in Traditional Chinese Medicine (TCM) to support mental health, memory, and emotional balance. In TCM, it is believed to "open the orifices of the heart," calm the spirit, and improve cognitive function. Historically, Polygala has been prescribed for symptoms like forgetfulness, insomnia, anxiety, and emotional disturbances—conditions thought to be related to the "Shen," or spirit, which corresponds loosely to what modern science describes as neurotransmitter balance.

Modern scientific research into Polygala's effects on neurotransmitter systems is limited but growing. Some preclinical studies indicate that extracts from Polygala tenuifolia may influence neurotransmitter levels, including acetylcholine, dopamine, and serotonin, primarily in animal models. The proposed mechanisms involve antioxidant effects, inhibition of acetylcholinesterase, and modulation of neuroinflammation. However, robust clinical evidence in humans is lacking.

Therefore, the primary justification for using Polygala to support the "Specific Neurotransmitters" body system is traditional, based on centuries of herbal practice rather than strong scientific validation. The evidence rating is 2, reflecting a traditional basis and limited preliminary scientific support, but a lack of high-quality clinical trials.

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