Synopsis

Source of validity: Scientific
Rating (out of 5): 4

SAMe (S-adenosyl-L-methionine) is primarily supported by scientific evidence for its role in the modulation of neurotransmitters, particularly in the context of mood regulation and depressive disorders. SAMe is a naturally occurring compound involved in methylation reactions that are critical for the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. Numerous clinical trials and meta-analyses have shown that SAMe supplementation can be effective in alleviating symptoms of major depressive disorder, especially in individuals who do not respond adequately to traditional antidepressants. For example, a 2016 meta-analysis in the journal CNS & Neurological Disorders - Drug Targets found that SAMe was significantly more effective than placebo and comparable to standard antidepressants in reducing depressive symptoms.

Mechanistically, SAMe increases the availability of neurotransmitters by donating methyl groups for their synthesis and metabolism. This biochemical role underpins its use in supporting the "Specific Neurotransmitters" body system, particularly where imbalances of serotonin or dopamine are implicated. While most research focuses on depression, there is also preliminary evidence suggesting benefits in cognitive function and other neuropsychiatric conditions, though these uses are less well-established.

Overall, the use of SAMe for supporting neurotransmitter systems is justified by moderate to strong scientific evidence, especially in the area of mood disorders. However, as with all supplements affecting neurotransmitters, clinical supervision is recommended due to potential interactions and side effects.

More about SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
More about Specific Neurotransmitters

Other ingredients that support Specific Neurotransmitters

Other body systems supported by SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)

Products containing SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)

Metagenics Blisphora®
Douglas Laboratories SAM-e
Designs For Health SAMe
Designs For Health SAMe
Pure Encapsulations SAMe (S-Adenosylmethionine)