Synopsis

Source of validity: Scientific
Rating (out of 5): 4

St. John’s Wort (Hypericum perforatum) is widely recognized for its use in supporting the neurotransmitter system, particularly in relation to mood regulation. Numerous clinical trials and meta-analyses have demonstrated that extracts of St. John’s Wort are more effective than placebo and as effective as some standard antidepressants (such as selective serotonin reuptake inhibitors, or SSRIs) in the treatment of mild to moderate depression. The mechanism is believed to involve the inhibition of the reuptake of key neurotransmitters, including serotonin, dopamine, and norepinephrine, thus increasing their availability in the synaptic cleft. The active constituents thought to be responsible for these effects include hypericin and hyperforin.

While St. John’s Wort has a long history of traditional use for mood-related complaints, its current support for the "Specific Neurotransmitters" body system is primarily justified by scientific evidence accumulated over the past few decades. However, it is important to note that while the evidence supporting its efficacy for mild to moderate depression is strong, it is less clear for severe depression or other psychiatric conditions. Additionally, St. John’s Wort is known to interact with various medications due to its induction of cytochrome P450 enzymes, which can affect the metabolism of drugs, including antidepressants, contraceptives, and anticoagulants.

In summary, St. John’s Wort is supported by substantial scientific evidence for its effects on neurotransmitter systems, specifically in the context of mood disorders.

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