Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Terpene lactones, particularly those found in Ginkgo biloba extract (such as ginkgolides and bilobalide), have been studied for their effects on the nervous system and neurotransmitter function. Scientific research suggests that these compounds may support cognitive function through several mechanisms, including modulation of neurotransmitter systems. Experimental studies indicate that terpene lactones can influence the uptake and activity of neurotransmitters such as dopamine, serotonin, and norepinephrine, potentially enhancing synaptic plasticity and neuroprotection. Clinical trials with standardized Ginkgo biloba extracts, which contain terpene lactones, have demonstrated modest improvements in cognitive performance and memory, particularly in elderly populations and those with mild cognitive impairment or dementia. However, the evidence is mixed, with some studies showing significant effects and others reporting minimal or no benefit. Overall, the use of terpene lactones to support specific neurotransmitter-related functions is supported by a moderate body of scientific literature, but findings are not universally conclusive. Further research is needed to clarify their precise mechanisms of action and efficacy in diverse populations.

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