Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tyrosine alpha-ketoglutarate is a compound combining the amino acid L-tyrosine with alpha-ketoglutaric acid. L-tyrosine is a well-known precursor for catecholamine neurotransmitters, including dopamine, norepinephrine, and epinephrine. Supplementation with L-tyrosine has been studied in the context of supporting neurotransmitter synthesis, particularly under conditions of stress or increased demand, where catecholamine stores may be depleted. Some research suggests that L-tyrosine supplementation can help maintain cognitive performance during acute stress, such as cold exposure, sleep deprivation, or multitasking. However, evidence for its use in general mood enhancement or cognitive function in non-stressed individuals is limited.

Alpha-ketoglutarate is an intermediate in the Krebs cycle and may theoretically aid in cellular energy metabolism, but its specific contribution to neurotransmitter support is not well studied. The combination of tyrosine and alpha-ketoglutarate is sometimes marketed for enhanced absorption or bioavailability, but there is little direct evidence supporting a synergistic effect for neurotransmitter support.

Overall, the use of Tyrosine alpha-ketoglutarate for supporting neurotransmitter function is based on the established role of L-tyrosine as a catecholamine precursor, with some scientific studies showing efficacy in specific, stress-related scenarios. The evidence is modest, warranting a rating of 2 out of 5.

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