Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Uridine monophosphate (UMP) has some scientific backing for its role in supporting the neurotransmitter system, though the evidence is largely preclinical or from small human studies. UMP is a pyrimidine nucleoside that is a precursor in the synthesis of RNA, and it plays a role in phospholipid biosynthesis, which is critical for neuronal membrane formation and function. Animal studies have demonstrated that oral supplementation with uridine (often in combination with choline and DHA) can enhance synaptic membrane formation, increase levels of key neurotransmitters such as dopamine and acetylcholine, and improve cognitive function and synaptic plasticity. For instance, a study by Wurtman et al. (2006) suggested that UMP, choline, and DHA supplementation increased synaptic protein levels and the number of dendritic spines in rats.

In humans, limited studies have examined UMP’s cognitive effects. Some small trials have explored its use in supporting memory in Alzheimer’s disease or age-related cognitive decline, but results are preliminary and not consistently replicated. There is insufficient large-scale clinical data to firmly establish UMP as a neurotransmitter-supporting supplement in healthy individuals. Theoretical rationale exists due to its role in brain phospholipid metabolism and neurotransmitter synthesis, but more robust clinical research is needed to draw definitive conclusions about its efficacy.

More about Uridine monophosphate
More about Specific Neurotransmitters

Other ingredients that support Specific Neurotransmitters

Other body systems supported by Uridine monophosphate

Products containing Uridine monophosphate