Evidence supporting the use of: Vitamin B6 (Mixed)
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6, also known as pyridoxine, is scientifically validated as an important cofactor in the synthesis of several neurotransmitters, including serotonin, dopamine, gamma-aminobutyric acid (GABA), and norepinephrine. B6 acts as a coenzyme for aromatic L-amino acid decarboxylase and glutamic acid decarboxylase, which are key enzymes in neurotransmitter biosynthesis. Deficiency in vitamin B6 can result in neurological symptoms such as irritability, depression, and confusion, which are likely related to impaired neurotransmitter production (NIH Office of Dietary Supplements). Clinical studies have shown that supplementation with vitamin B6 can improve symptoms in certain neurological and psychiatric conditions, such as premenstrual syndrome (PMS) and some forms of epilepsy, likely due to its role in modulating neurotransmitter synthesis (PubMed PMC6716756). However, while B6 is essential for neurotransmitter function, evidence for supplementation benefiting the general population without deficiency is limited. Overall, there is solid biochemical and clinical evidence supporting the use of vitamin B6 for supporting the neurotransmitter system, particularly in cases of deficiency or increased physiological demand.

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