Evidence supporting the use of: Vitamin B6 (various)
For the body system: Specific Neurotransmitters

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6, also known as pyridoxine, plays a crucial role in neurotransmitter synthesis and function, which underpins its use in supporting the "Specific Neurotransmitters" body system. Scientifically, B6 is an essential coenzyme in the biosynthesis of several key neurotransmitters, including serotonin, dopamine, gamma-aminobutyric acid (GABA), and norepinephrine. Pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, facilitates the decarboxylation and transamination reactions necessary for these neurotransmitters’ formation from their amino acid precursors.

Clinical and biochemical studies have shown that B6 deficiency is associated with altered neurotransmitter levels, leading to symptoms such as irritability, depression, and cognitive dysfunction. Supplementation with vitamin B6 has been shown to improve symptoms in certain neurological and psychiatric conditions, such as depression and premenstrual syndrome (PMS), likely through modulation of serotonin and GABA synthesis. For example, a 2017 review in Frontiers in Nutrition highlights the vitamin’s importance in cognitive development and mood regulation.

Overall, the scientific evidence supporting the role of vitamin B6 in neurotransmitter function is strong, particularly at the biochemical level, and there is clinical data in specific populations. Therefore, its use to support neurotransmitter-related body systems is scientifically justified.

More about Vitamin B6 (various)
More about Specific Neurotransmitters

Products containing Vitamin B6 (various)

We currently have no products on Vitabase that contain this ingredient.