Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperidin methyl chalcone is a modified form of the flavonoid hesperidin, which is found naturally in citrus fruits. It is commonly included in dietary supplements and topical products aimed at supporting venous health, including the appearance of spider veins (telangiectasia). The main rationale for its use is based on its purported ability to strengthen capillaries, reduce capillary permeability, and improve microcirculation, thereby potentially reducing the visibility and progression of spider veins.

Scientific evidence for hesperidin methyl chalcone specifically in the treatment of spider veins is limited. Most supporting research focuses on chronic venous insufficiency and related symptoms (such as leg swelling, heaviness, and varicose veins) rather than isolated spider veins. Clinical studies, often conducted with micronized purified flavonoid fractions (a combination of diosmin and hesperidin), have demonstrated modest benefits in improving venous tone and reducing symptoms of venous disease. However, direct studies on spider veins are sparse, and most evidence comes from broader studies on venous insufficiency or from the pharmacological actions of flavonoids in general.

Overall, while there is some scientific rationale and modest clinical evidence supporting the use of hesperidin methyl chalcone for venous health, the direct evidence for its efficacy in treating or supporting spider veins specifically is weak. The strength of evidence is therefore rated as 2 out of 5.

More about Hesperidin methyl chalcone
More about Spider Veins

Other ingredients used for Spider Veins

Other health conditions supported by Hesperidin methyl chalcone

Products containing Hesperidin methyl chalcone