Evidence supporting the use of: Collagen
For the body system: Spinal Disks

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Collagen is a major structural protein in the human body and is an essential component of intervertebral disks, particularly within the annulus fibrosus and nucleus pulposus. Scientific interest in collagen supplementation for spinal disk health is based on the premise that oral collagen peptides may support connective tissue regeneration or reduce degeneration. However, direct clinical evidence specifically linking collagen supplementation to improved spinal disk health is limited. Most available studies focus on collagen’s benefits for joint health (such as in osteoarthritis) and skin elasticity, with some preclinical data suggesting potential support for connective tissue repair. Animal studies and in vitro models have shown that collagen can influence extracellular matrix synthesis and potentially mitigate intervertebral disk degeneration, but large, high-quality human trials are lacking. Thus, while there is a scientific rationale for collagen’s use in supporting spinal disks, and some preliminary evidence, the overall strength of evidence remains modest. Therefore, collagen is used to support the spinal disks based on scientific reasoning and early-stage research, but robust validation in human populations is currently insufficient.

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