Collagen II, also known as type II collagen, is a major structural protein in cartilage, which forms a key component of spinal disks (intervertebral disks). Scientific research has focused on its potential to support joint and cartilage health, including the spinal disks, by providing the specific amino acids and structural framework necessary for cartilage repair and maintenance. Oral supplementation with undenatured type II collagen has been shown in several animal and human studies to modulate immune responses that can contribute to cartilage degradation, and may help reduce symptoms related to cartilage wear, such as pain and stiffness, particularly in osteoarthritis. Some preclinical studies have demonstrated improved cartilage integrity and biomechanical properties in spinal disks following collagen supplementation. However, direct clinical evidence specifically evaluating the efficacy of collagen II for spinal disk health (as opposed to general joint or cartilage health) is limited, and most human trials focus on knee or other peripheral joints. The available evidence supports a plausible benefit, particularly in the context of overall cartilage and connective tissue support, but further research is needed to establish definitive efficacy for the spinal disks themselves.