Glehnia littoralis, known in traditional Chinese medicine (TCM) as "Bei Sha Shen" (北沙参), has been used for centuries primarily to nourish lung yin and moisten dryness. However, it is sometimes included in formulas aimed at supporting the Spleen, particularly when Spleen deficiency is accompanied by dryness or when there is an overlap of Lung and Spleen disorders. The classical TCM concept of the Spleen encompasses digestive and assimilative functions, and many herbs that moisten dryness or replenish fluids are thought to indirectly benefit the Spleen, especially in cases of "Spleen yin deficiency" or when digestive weakness leads to dryness of the body fluids.

Despite its occasional use in formulas that target the Spleen, the primary traditional indications for Glehnia littoralis remain focused on the Lungs and Stomach, especially for dry cough, hoarse voice, and dry mouth or throat. The herb’s moistening properties are believed to help support fluid production and indirectly aid digestion in some traditional frameworks. There is limited direct traditional evidence supporting its specific action on the Spleen, and it is not categorized as a principal Spleen tonic like Dang Shen (Codonopsis) or Bai Zhu (Atractylodes).

Scientific evidence regarding Glehnia littoralis for Spleen function is lacking, and most pharmacological research focuses on its anti-inflammatory, immunomodulatory, and lung-protective effects. Thus, its use for Spleen support is rooted in tradition rather than modern scientific validation.