Polygonatum (commonly known as Solomon's Seal, and referred to as Huang Jing in Chinese medicine) is used traditionally in Chinese herbal medicine to support the Spleen body system. In Traditional Chinese Medicine (TCM), the Spleen is believed to govern digestion and the transformation of food into qi (vital energy) and blood. Polygonatum species, especially Polygonatum sibiricum and Polygonatum odoratum, are categorized as herbs that "tonify qi" and "nourish yin." They are often included in formulas intended to address symptoms such as fatigue, loss of appetite, and weakness, which TCM associates with Spleen Qi Deficiency.

The justification for Polygonatum's use in supporting the Spleen system is rooted in centuries of empirical use within TCM rather than in rigorous scientific studies. Classical texts such as the Shennong Bencao Jing (Divine Farmer's Materia Medica) mention Polygonatum as a superior tonic herb. Modern pharmacological studies have focused more on its antioxidant, anti-inflammatory, and immune-modulating effects, with limited direct investigation into its impact on digestive function or the biomedical equivalent of the Spleen. Therefore, while there is substantial traditional use and some general bioactivity research, high-quality clinical evidence supporting its efficacy for "Spleen" health specifically is lacking.