Split Gills Fungus (Schizophyllum commune) has a history of use in traditional medicine, particularly in East and Southeast Asia. In Traditional Chinese Medicine (TCM), mushrooms are often used to support various organs, including the Spleen, which is considered central to digestion and energy production. While S. commune itself is not among the most prominent spleen-tonifying mushrooms compared to others like Ganoderma lucidum (Reishi) or Grifola frondosa (Maitake), it has been employed in folk remedies for general immune support and strengthening the body, which TCM associates with spleen health.

The traditional rationale comes from the TCM perspective that "Qi" (vital energy) is bolstered by mushrooms, and the spleen is vital in generating and managing Qi. Split Gills Fungus is sometimes included in herbal formulations aimed at improving digestion and vitality. However, direct references to its effects on the Spleen in classical texts are limited, and its reputation is based more on its general medicinal properties and adaptogenic effects than on specific organ targeting.

Modern scientific research has identified immune-modulating and anti-inflammatory properties in S. commune, but studies have not specifically confirmed benefits for the spleen or digestive health. Thus, its use for supporting the Spleen body system remains rooted mainly in tradition, with modest supporting evidence.