Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cissus quadrangularis has a long history of use in traditional medicine systems, particularly in Ayurveda, for the treatment of bone fractures, joint pain, and sprains. In recent years, there has been increasing scientific interest in its potential benefits for musculoskeletal injuries, including sprains. Animal studies and a limited number of clinical trials suggest that extracts of Cissus quadrangularis may help reduce inflammation, promote collagen synthesis, and accelerate the healing of soft tissue injuries. For example, preclinical research has demonstrated anti-inflammatory and analgesic effects, while some human studies have reported faster recovery and reduced pain/swelling in individuals with sports-related injuries (including ligament sprains) when using Cissus-based supplements. However, the quality of evidence is variable, with many studies being small, lacking rigorous controls, or being conducted in combination with other interventions. While the scientific evidence is promising and supports the traditional use of Cissus quadrangularis for sprains, more high-quality, large-scale clinical trials are needed to firmly establish both efficacy and optimal dosing. Overall, its use for sprain support is justified by a combination of traditional usage and emerging, though moderate, scientific validation.

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