Enzyme blends, especially those containing proteolytic enzymes such as bromelain, trypsin, chymotrypsin, and serratiopeptidase, have been investigated for their potential to support recovery from sprains and soft tissue injuries. The scientific basis for their use lies primarily in their proposed anti-inflammatory and fibrinolytic properties. Several clinical studies and reviews suggest that oral proteolytic enzyme supplementation may reduce swelling, pain, and recovery time in acute musculoskeletal injuries, including sprains. For example, a number of randomized controlled trials have compared enzyme blends to nonsteroidal anti-inflammatory drugs (NSAIDs) and placebo, with some studies showing comparable efficacy in pain reduction and improvement of functional outcomes. Bromelain, in particular, has a moderate level of evidence supporting its use for reducing inflammation and edema following trauma or surgery.

However, the quality of evidence varies, with some studies having methodological limitations such as small sample sizes or lack of blinding. Meta-analyses generally conclude that while enzyme blends may be beneficial as adjuncts in the management of sprains, their effects are modest and more high-quality research is needed. Safety profiles are generally favorable, though gastrointestinal side effects can occur. In summary, there is moderate scientific evidence that enzyme blends can aid in the management of sprains, but they should not replace standard care.