Evidence supporting the use of: Glycosaminoglycans
For the health condition: Sprains

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycosaminoglycans (GAGs), such as chondroitin sulfate and hyaluronic acid, are naturally occurring polysaccharides found in connective tissues, including cartilage, tendons, and ligaments. Their primary role is to maintain structural integrity and facilitate tissue repair. The rationale for using GAGs to support or treat sprains (acute ligament or tendon injuries) is based on their function in promoting extracellular matrix synthesis and modulating inflammation.

Some experimental and limited clinical studies have investigated the effects of oral or injectable GAGs in the context of soft tissue injury, including sprains. For example, animal models suggest that GAG supplementation may enhance collagen synthesis and reduce inflammation during tendon healing. However, high-quality human clinical trials specifically evaluating GAGs for the treatment of acute sprains are sparse. Most clinical research has focused on osteoarthritis and chronic joint conditions, where some benefit has been observed, particularly for symptom relief.

Overall, while there is some mechanistic and preclinical evidence supporting a potential role for GAGs in connective tissue repair, definitive clinical evidence for their effectiveness in treating sprains is limited. Therefore, the evidence rating is modest (2 out of 5), reflecting promising but unproven benefit in this specific context.

More about Glycosaminoglycans
More about Sprains

Other health conditions supported by Glycosaminoglycans

Arthritis
Cartilage Damage
Inflammation
Scars / Scar Tissue
Sprains
Wounds and Sores

Products containing Glycosaminoglycans

We currently have no products on Vitabase that contain this ingredient.