Evidence supporting the use of: Methylsulfonylmethane (MSM)
For the health condition: Sprains

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylsulfonylmethane (MSM) is commonly marketed as a dietary supplement for joint health and musculoskeletal injuries, including sprains. The scientific evidence supporting MSM for the treatment of sprains is limited but exists, primarily extrapolated from studies on its anti-inflammatory and analgesic properties in broader musculoskeletal conditions. A few randomized controlled trials and animal studies suggest that MSM may reduce exercise-induced muscle damage, inflammation, and oxidative stress, which are relevant to the healing process following a sprain. For example, one study found that MSM supplementation reduced levels of inflammatory biomarkers and muscle soreness in healthy individuals after strenuous exercise. Another trial in patients with osteoarthritis showed reduced pain and improved function with MSM supplementation compared to placebo, likely due to its anti-inflammatory effects.

However, direct clinical trials investigating MSM specifically for acute sprains are lacking. Most human evidence is indirect or based on its efficacy in similar conditions involving inflammation and soft tissue injury. There is also some traditional and anecdotal use of MSM for musculoskeletal injuries, but these are not robustly documented in the scientific literature. In summary, while there is a plausible biological mechanism and some supportive evidence for MSM's benefit in conditions involving inflammation and soft tissue damage, the direct evidence for its use in sprain treatment is weak (rated 2/5), and further targeted clinical research is needed.

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