Evidence supporting the use of: Glycerol monolaureate
For the health condition: Staph Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycerol monolaurate (GML), also known as monolaurin, has been investigated for its antimicrobial properties, particularly against Staphylococcus aureus (including MRSA). Several in vitro studies have demonstrated that GML can inhibit the growth of various Gram-positive bacteria by disrupting cell membranes and interfering with bacterial signaling pathways. Research published in peer-reviewed journals has shown that GML exhibits significant bactericidal activity against Staphylococcus species, including both planktonic and biofilm forms. For example, a 2008 study in "Antimicrobial Agents and Chemotherapy" (Schlievert et al.) found that GML was effective at inhibiting the growth and exotoxin production of S. aureus strains. Further, animal studies indicate that topical application of GML can reduce severity and incidence of skin infections caused by staphylococci.

However, while the laboratory and preclinical evidence is promising, clinical data in humans remain limited. No large-scale randomized controlled trials have established its efficacy or safety for treating staph infections in patients, though it is used in some topical formulations and medical device coatings. Therefore, the use of GML for staph infections is justified by scientific evidence at the preclinical level, but lacks robust clinical validation at present. The overall strength of evidence is moderate (3/5), pending further human studies.

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