The use of the Pepper Bark Tree (Warburgia salutaris) to support or treat Staph infections is primarily based on traditional medicine rather than robust scientific validation. In various Southern African ethnomedical practices, the bark and leaves of Warburgia salutaris have been used to treat a range of infections, including those of the skin, respiratory tract, and digestive system, which may include conditions suspected to be caused by Staphylococcus species. These uses are rooted in the plant's reputation for possessing antimicrobial properties, as observed by traditional healers.

Some laboratory studies have shown that extracts of Warburgia salutaris possess general antimicrobial activity against several pathogens, including Staphylococcus aureus. However, these studies are limited in scope, mostly in vitro, and do not provide conclusive evidence for clinical efficacy against staph infections in humans. There are no published clinical trials or comprehensive scientific reviews confirming its effectiveness or safety for this specific use. Thus, while traditional use exists and preliminary in vitro evidence suggests some antimicrobial action, the overall level of evidence supporting its use specifically for staph infections is low and does not meet modern scientific standards.