Pokeweed (Phytolacca americana) has a long history of use in traditional herbal medicine, particularly among Native American and Appalachian communities. Traditionally, various parts of the pokeweed plant, especially the root, have been used topically as poultices or salves to address skin infections, abscesses, and boils, which may include those caused by Staphylococcus bacteria. Some herbal practitioners have historically believed pokeweed to have "drawing" properties to help expel infection and reduce inflammation.

However, scientific evidence supporting the efficacy and safety of pokeweed for treating Staph infections is minimal. While in vitro studies have identified certain pokeweed proteins (notably pokeweed antiviral protein, or PAP) with antimicrobial and antiviral properties, there is no robust clinical research validating its effectiveness or safety for treating bacterial infections in humans, particularly Staphylococcus aureus. Furthermore, the plant is considered toxic, with the potential for serious side effects if used internally or improperly.

In summary, pokeweed’s use for Staph infections is based primarily on traditional practices rather than scientific validation. The evidence base is very weak (rated 1 out of 5), and safety concerns further limit its practical application in modern herbal medicine.