Smilax species, commonly known as sarsaparilla, have a long history of use in traditional medicine systems, particularly in Central and South America, as well as in traditional Chinese medicine. Historically, Smilax has been used as a tonic and for treating various skin conditions, including those believed to be caused by infections such as boils, abscesses, and ulcers, some of which may have been due to Staphylococcus bacteria. Ethnobotanical records describe Smilax roots being applied topically or ingested as decoctions to "purify the blood" and manage skin eruptions.

Regarding Staph infections specifically, the traditional use is based on empirical observation rather than a scientific understanding of microbial pathogens. While Smilax does contain some phytochemicals such as saponins, flavonoids, and phenolic compounds, which in vitro show weak to moderate antimicrobial activities, there is minimal direct scientific evidence supporting its effectiveness specifically against Staphylococcus aureus or related pathogens. No clinical studies have validated its use for Staph infections, and any antibacterial effect observed in laboratory settings is not robust enough to recommend Smilax as a reliable treatment.

In summary, Smilax is used for skin infections in traditional medicine, which may sometimes involve Staph, but there is little scientific validation for this application. Its traditional use persists, but it should not be considered a substitute for evidence-based treatments for Staph infections.