Evidence supporting the use of: Terpinen-4-ol
For the health condition: Staph Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Terpinen-4-ol is a major active component of tea tree oil (Melaleuca alternifolia) and is credited with much of its antimicrobial activity. Several in vitro studies have demonstrated that terpinen-4-ol exhibits antibacterial effects against Staphylococcus aureus, including methicillin-resistant strains (MRSA). For instance, laboratory experiments have shown that terpinen-4-ol can disrupt bacterial cell membranes and inhibit bacterial growth at certain concentrations. However, most of the supporting data derive from in vitro (laboratory) studies rather than human clinical trials.

Clinical evidence is limited. A few small studies and case reports suggest potential for topical tea tree oil preparations (which contain terpinen-4-ol) in managing superficial skin infections, but robust, well-controlled clinical trials specifically investigating terpinen-4-ol alone for Staph infections in humans are lacking. Additionally, concerns about skin irritation and allergic reactions with topical application exist. Thus, while there is a scientific rationale and preliminary laboratory evidence for terpinen-4-ol’s antibacterial activity against Staph species, clinical evidence supporting its use as a treatment for Staph infections—especially in a medical context—is not strong. Current recommendations do not support its use as a replacement for standard medical treatments.

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Products containing Terpinen-4-ol

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