Relationship: Stress and Acetyl-L-Tyrosine

Evidence supporting the use of: Acetyl-L-Tyrosine
For the health condition: Stress

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Source of validity: Scientific
Rating (out of 5): 2

Acetyl-L-Tyrosine is a modified form of the amino acid L-tyrosine, often used as a dietary supplement purported to support cognitive function and stress resilience. The rationale for its use in stress is rooted in its role as a precursor to catecholamine neurotransmitters such as dopamine, norepinephrine, and epinephrine, which are involved in the body's response to stress. Scientific evidence supporting Acetyl-L-Tyrosine’s efficacy for stress is modest. Several human studies have examined L-tyrosine supplementation (not always specifically the acetyl form) in situations of acute stress, such as cold exposure, sleep deprivation, or cognitive overload. These studies suggest that tyrosine supplementation may help maintain cognitive performance and working memory under stress, likely by replenishing neurotransmitter levels that become depleted during stressful conditions.

However, the evidence is not robust, and most studies are small, short-term, and often use L-tyrosine rather than Acetyl-L-Tyrosine specifically. There is limited direct clinical research comparing the acetylated version to standard L-tyrosine, though Acetyl-L-Tyrosine is believed to have better solubility and potential bioavailability. The use of tyrosine supplements for general, chronic psychological stress is not well-supported. Thus, while there is some scientific backing for its use in acute stress scenarios, the overall evidence base is limited, and more research is needed to make definitive recommendations.

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Evidence supporting the use of: Acetyl-L-Tyrosine
For the health condition: Stress

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Evidence supporting the use of: Acetyl-L-TyrosineFor the health condition: Stress

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Other health conditions supported by Acetyl-L-Tyrosine

Products containing Acetyl-L-Tyrosine

Evidence supporting the use of: Acetyl-L-Tyrosine
For the health condition: Stress