Evidence supporting the use of: Bacopa glycoside (unspecified)
For the health condition: Stress
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Bacopa glycosides, particularly the active compounds known as bacosides found in Bacopa monnieri (also called Brahmi), have been investigated for their potential to support stress resilience and reduce anxiety. Bacopa has a long history of use in Ayurvedic medicine as a "medhya rasayana" (nootropic and adaptogen), traditionally employed to enhance cognition and support adaptation to stress. In modern research, several randomized controlled trials and animal studies provide preliminary evidence for its stress-relieving effects. Studies suggest that Bacopa extracts may reduce levels of cortisol and modulate neurotransmitter systems involved in the stress response, such as serotonin and dopamine. Human studies, though generally of moderate quality and often using whole plant extracts rather than isolated glycosides, have reported reductions in perceived stress and anxiety scores as well as improvements in mood and cognitive performance in stressed individuals. The mechanisms are thought to involve antioxidant activity, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, and neuroprotective effects. However, most clinical studies use standardized Bacopa extracts (standardized for bacosides) and not isolated or unspecified "Bacopa glycoside," making translation of results to unspecified preparations less direct. While the overall evidence supports a role for Bacopa in stress adaptation, more rigorous trials are needed to confirm efficacy and optimal dosing, especially with respect to specific glycosides.
Other ingredients used for Stress
5-Hydroxytryptophan (5-HTP)7-Keto-DHEA
acetyl l-carnitine
alpha-pinene
arjun tree
ashwagandha
asparagus
astragalus
waterhyssop
benegut perilla (proprietary)
bergamot
bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
sesame
black tea
bonito peptide
bupleurum falcatum
California poppy
caterpillar mushroom
chaga mushroom
chamomile
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
GABA (gamma aminobutyric acid)
gardenia
gotu kola
green tea
guayusa
heartwood
hibiscus
hops
jujube
kava root
kudzu
l-ornithine
l-taurine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lactobacillus brevis
lactobacillus casei
lactobacillus helveticus
lactiplantibacillus plantarum
lavender
lentinula edodes mycelia
lion's mane
liquid liver fractions
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
Acetyl-L-Tyrosine
oat
passionflower
peppermint oil
perilla
phosphatidylserine
phospholipids
pine bark
polygala root
pregnenolone
pyrroloquinoline disodium salt
quail egg
relora® (proprietary)
rhodiola
rose oil
saffron
sceletium
black ginger
skullcap
spearmint leaf
spinach
valerian root
velvet bean
vitamin B12
vitamin B6
mulberry
whole adrenal glandular
zinc
sarsaparilla
suma
jiaogulan
catnip
cardamom
anise
fumaria parviflora
bee pollen
lingzhi
kanna
silk tree
oriental arborvitae
anemarrhena asphodeloides
St. John's Wort
yerba mate
noni
wood betony
biota seed
goji berry
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
7,8-Dihydroxyflavone
Aralia
Arjuna
akebia
Antler
Agastache
Agrimony
Apigenin
Antrodia camphorata
Arginine aspartate
Albizia
Anserina
Agmatine
Agarwood
Alpha lactalbumin
Algal protein
Betony
Baikal Skullcap
Black spruce
Baccosides
Bacopin
Baicalein
Basidiomycota
Banyan
Brahmi
Bacopa
Buddha's Hand
Borage
banana
Bifidobacteria
Bupleurum
bacoside
Baicalin
Bird's nest
Centella triterpenes
Common Monkey Flower
Clary sage
Chinese Mountain Ant
Codonopsis
Coriander
Clerodendrum phlomidis
Chinese Fleeceflower
Chuchuhuasi
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Coca
Chocolate
Capitate Valerian
Corktree
Catuaba
C-Phycocyanin
cypress
Cowslip
Calamus
Cherimoya
Convolvulus prostratus
Corydalis
Convolvulus Pluricaulis
Celastrus
Canscora
Dismutase
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dibenzo-alpha pyrones
Devil's Club
Date
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Eplotab
Erythrina
Emblicanin
Goldthread
Glycine
jasmine
Lotus
Mistletoe
Mimosa
Orchid
Poppy
Pistachio
Rose
Spikenard
yohimbine
Other health conditions supported by Bacopa glycoside (unspecified)
Alzheimer's DiseaseAnxiety
Anxiety Disorders
Attention Deficit Disorder
Dementia
Depression
Fatigue
Inflammation
Insomnia
Memory and Brain Function
Stress