Evidence supporting the use of: Ginsenosides
For the health condition: Stress

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginsenosides are the primary active compounds found in ginseng, particularly Panax ginseng, and have been studied for their potential to help the body cope with stress. The traditional use of ginseng as an "adaptogen"—a substance believed to increase resistance to physical, chemical, and biological stressors—dates back hundreds of years in East Asian medicine. However, modern scientific research has begun to investigate these claims more rigorously.

Experimental studies suggest that ginsenosides may exert anti-stress effects by modulating the hypothalamic-pituitary-adrenal (HPA) axis and influencing levels of stress hormones such as cortisol. Some animal studies have shown that ginsenosides can reduce markers of stress and improve behavioral responses in stressful conditions. Limited human studies and clinical trials indicate potential benefits in improving mood, reducing fatigue, and enhancing overall psychological well-being under stress, but results are inconsistent and often limited by small sample sizes or methodological flaws.

Systematic reviews and meta-analyses (e.g., Kennedy et al., 2001; Reay et al., 2005) conclude that while there is some evidence for the anti-stress effects of ginseng/ginsenosides, it is not robust or conclusive. The overall strength of scientific evidence is modest, and more high-quality, large-scale clinical trials are needed to confirm efficacy. Thus, while there is a scientific basis for the use of ginsenosides in stress support, the evidence is limited and not yet definitive.

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Products containing Ginsenosides

We currently have no products on Vitabase that contain this ingredient.