Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Griffonia simplicifolia is a West African plant whose seeds are a natural source of 5-hydroxytryptophan (5-HTP), a direct precursor to the neurotransmitter serotonin. Serotonin is implicated in mood regulation, anxiety, and stress response. Several small clinical studies and animal experiments have investigated the effects of 5-HTP supplementation on mood and stress-related symptoms. Some evidence suggests that oral 5-HTP can improve mood and reduce symptoms associated with stress, anxiety, and depression, likely due to increased serotonin synthesis in the brain. However, the majority of these studies use isolated 5-HTP rather than Griffonia simplicifolia seed extract specifically, and sample sizes are often small.

There is limited direct clinical evidence on Griffonia simplicifolia itself for stress, but its use is scientifically rationalized by its 5-HTP content. The European Food Safety Authority (EFSA) and other regulatory bodies note insufficient robust evidence for health claims related to stress or mood. Overall, while there is a plausible mechanism and some supportive data for 5-HTP (and by extension Griffonia simplicifolia) in stress reduction, the quality and quantity of direct clinical evidence remain limited, justifying a modest evidence rating.

More about Griffonia simplicifolia
More about Stress

Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7-Keto-DHEA
Acetyl L-carnitine
alpha-pinene
arjun tree
ashwagandha
asparagus
astragalus
waterhyssop
benegut perilla (proprietary)
bergamot
bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
sesame
black tea
bonito peptide
bupleurum falcatum
California poppy
caterpillar mushroom
chaga mushroom
chamomile
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
GABA (gamma aminobutyric acid)
gardenia
gotu kola
green tea
guayusa
heartwood
hibiscus
hops
jujube
kava
kudzu
L-Ornithine
L-taurine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
lactobacillus brevis
lactobacillus casei
lactobacillus helveticus
lactiplantibacillus plantarum
lavender
lentinula edodes mycelia
lion's mane
liquid liver fractions
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
Acetyl-L-Tyrosine
oat
passionflower
Peppermint
perilla
phosphatidylserine
phospholipids
pine bark
polygala root
pregnenolone
pyrroloquinoline disodium salt
quail egg
relora® (proprietary)
rhodiola
rose oil
saffron
sceletium
black ginger
skullcap
spearmint leaf
spinach
valerian root
velvet bean
vitamin B12
vitamin B6
mulberry
whole adrenal glandular
zinc
sarsaparilla
suma
jiaogulan
catnip
cardamom
anise
fumaria parviflora
bee pollen
lingzhi
kanna
silk tree
oriental arborvitae
anemarrhena asphodeloides
St. John's Wort
yerba mate
noni
wood betony
biota seed
goji berry
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
star of Bethlehem
7,8-Dihydroxyflavone
Aralia
Arjuna
Akebia
Antler
Agastache
Agrimony
Apigenin
Antrodia camphorata
Arginine aspartate
Albizia
Anserina
Agmatine
Agarwood
Alpha lactalbumin
Algal protein
Betony
Baikal Skullcap
Black spruce
Baccosides
Bacopin
Baicalein
Basidiomycota
Banyan
Brahmi
Bacopa
Buddha's Hand
Borage
banana
Bifidobacteria
Bupleurum
bacoside
Baicalin
Bird's nest
Centella triterpenes
Monkey Flower
Clary sage
Chinese Mountain Ant
Codonopsis
Coriander
Clerodendrum phlomidis
Chinese Fleeceflower
Chuchuhuasi
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Coca
Chocolate
Capitate Valerian
Corktree
Catuaba
C-Phycocyanin
cypress
Cowslip
Calamus
Cherimoya
Convolvulus prostratus
Corydalis
Convolvulus Pluricaulis
Celastrus
Canscora
Dismutase
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dibenzo-alpha pyrones
Devil's Club
Date
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Eplotab
Erythrina
Emblicanin
Eurycoma Longifolia
Fo-Ti
Fragrant Rosewood
Ficus religiosa
Fish
Frankincense
Flavones
Goldthread
Gelsemium
Ginsenosides
Griffonia simplicifolia
gum
Galactooligosaccharides
Glycine
Gastrodin
Honokiol
Hemidesmus
Homalomena
Hypericum
Hericium mushroom
Honeybush
isoliquiritigenin
Japanese Kadsura
jasmine
Jujubosides
Jatamansi
Kavalactones
Kukicha
Kola Nut
Kuding tea
Lycium
lemon balm
Lactucarium
Linden
Lactococcus rhamnosus
Lactucopicrin
Limonene
Longan
Lavandin
Lotus
Leptadenia
Large-Leaved Linden
Lupulinum
Lactalbumin
Mentha haplocalyx
Macamides
Mandarin
Maral Root
Mangiferin
Myrcene
Mung Bean
Marjoram
Mimulus
Mistletoe
Methylxanthine
Mimosa
Meadow sage
Mate
Magnolol
Mulungu
Macaenes
Mesembrine
Nardostachys
Night jessamine
Nymphaea caerulea
Oolong Tea
Orchid
Oxindole alkaloids
Pyrroloquinoline Quinone
Piper chaba
Patchouli oil
Pepper Bark Tree
Pentatropis capensis
Passionfruit
Poppy
Pistachio
Polygala
Purple Monkeyflower
Rosavins
Rosabin
Rauvolfia
Rehmannia
Rose
Rooibos
Speedwell
Sumbul
Spikenard
Scleranthus annus
Salidroside
Safed musli
Sarivan
Shankhpushpi
Sweet Woodruff
Schisandrins
Sida cordifolia
Semecarpus anacardium
Stachytarpheta cayennensis
Schizandrol A
Shataverins
Sandy Everlasting
Shilajit
Saffranal
Tetracyclic oxindole alkaloids
Traveler's Joy
Trichilia catigua
Taxillus chinensis
Trichopus zeylanicus
Taurine
Tagara
Tetrahydropalmatine
Uncaria
Vetiver
Valerenic acid
Vine tea
Vitexin
Viburnum
Verbena
Vanilla
Withanolides
Wogonin
Xanthine
Xanthophyll
Xylaria nigripes
Xanthone
Yuzu
Yellow-Fruit Nightshade
Yumberry
yohimbine
Ylang ylang

Other health conditions supported by Griffonia simplicifolia

Anxiety
Anxiety Disorders
Depression
Sleep (restless and disturbed)
Stress

Products containing Griffonia simplicifolia

We currently have no products on Vitabase that contain this ingredient.