Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactiplantibacillus plantarum is a probiotic bacterium that has been investigated for its potential to support mental health, including stress reduction. While its use for stress is not rooted in traditional medicine, there is a growing body of preclinical and clinical research exploring the gut-brain axis and the impact of probiotics on mood and stress-related outcomes. Several animal studies have demonstrated that supplementation with L. plantarum can modulate the hypothalamic-pituitary-adrenal (HPA) axis, reduce corticosterone levels, and improve stress-related behaviors. Human studies are fewer but present; small randomized controlled trials have suggested that L. plantarum supplementation may help reduce perceived stress and improve mood, potentially through anti-inflammatory effects and modulation of neurotransmitter production (such as GABA and serotonin). For example, a 2021 double-blind placebo-controlled study found that a multi-strain probiotic containing L. plantarum reduced psychological stress in healthy adults. However, these findings are preliminary and often involve multi-strain formulations, making it difficult to isolate the effect of L. plantarum specifically. Larger, well-designed human trials are needed to confirm efficacy and clarify mechanisms. In summary, there is some scientific evidence supporting the use of L. plantarum for stress, but it remains limited and inconclusive, warranting a moderate evidence rating.

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Other health conditions supported by lactiplantibacillus plantarum

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