Evidence supporting the use of: Mangiferin
For the health condition: Stress

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mangiferin, a polyphenolic compound primarily extracted from mango leaves and bark, has been investigated for its potential adaptogenic and anti-stress effects in several preclinical studies. Animal research indicates that mangiferin may alleviate stress-induced biochemical and behavioral changes, possibly by modulating the hypothalamic-pituitary-adrenal (HPA) axis and exerting antioxidant effects. Specifically, studies in rodents have demonstrated that mangiferin administration can reduce biomarkers of stress such as corticosterone, decrease anxiety-like behaviors, and protect against oxidative damage induced by stressors. The compound’s anti-inflammatory and neuroprotective properties are also considered relevant to its potential anti-stress effects.

However, the current evidence is largely limited to in vitro and animal models, with a lack of substantial human clinical data. While these findings suggest a plausible mechanism by which mangiferin could help mitigate stress, there have not been robust clinical trials in humans confirming its efficacy or safety for this purpose. Thus, the scientific evidence supporting mangiferin’s use for stress is preliminary, and rated as moderate to low strength (2 out of 5), pending further human research. There is no strong tradition of mangiferin’s use for stress relief in historical or ethnobotanical records; its modern use is primarily driven by emerging scientific research rather than longstanding traditional practices.

More about mangiferin
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Products containing mangiferin

We currently have no products on Vitabase that contain this ingredient.