Evidence supporting the use of: Vitamin B6 (Pyridoxine HCl)
For the health condition: Stress

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (Pyridoxine HCl) is sometimes included in supplements aimed at reducing stress, primarily due to its role in neurotransmitter synthesis and overall brain health. Scientifically, Vitamin B6 is essential for the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), which are involved in regulating mood and emotional responses. Deficiency in Vitamin B6 has been associated with mood disorders, including depression and irritability, which are sometimes components of stress. However, clinical studies specifically examining Vitamin B6 supplementation for the treatment or mitigation of stress in otherwise healthy individuals are limited. Some small studies and reviews suggest that supplementation may have a modest benefit on mood and psychological stress, particularly in individuals with low baseline B6 status or in combination with other B vitamins. However, the evidence is mixed and often confounded by co-administration with other nutrients or lack of control for baseline deficiency.

Overall, while there is a plausible biological mechanism and some preliminary evidence, robust, high-quality clinical trials directly supporting the use of Vitamin B6 for stress management are lacking. Its use in this context is better supported by its general role in mental health and neurotransmitter function rather than direct evidence for stress reduction. Therefore, the evidence rating is moderate-low.

More about Vitamin B6 (Pyridoxine HCl)
More about Stress

Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7-Keto-DHEA
Acetyl L-carnitine
alpha-pinene
arjun tree
ashwagandha
asparagus
astragalus
Waterhyssop
benegut perilla (proprietary)
bergamot
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum
sesame
black tea
bonito peptide
bupleurum falcatum
California poppy
caterpillar mushroom
chaga mushroom
chamomile
cordyceps
curcumin
damiana
DHA (docosahexaenoic acid)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
GABA (gamma aminobutyric acid)
gardenia
gotu kola
green tea
guayusa
heartwood
hibiscus
hops
jujube
kava
kudzu
L-ornithine
L-taurine
L-theanine
L-tryptophan
l-tyrosine
lactium casein decapeptide
Lactobacillus brevis
Lactobacillus casei
Lactobacillus helveticus
lactiplantibacillus plantarum
lavender
Lentinula edodes mycelia
lion's mane
liquid liver fractions
maca
magnesium
magnolia
Matcha
Melatonin
Mint
Motherwort
Muira puama
Acetyl-L-Tyrosine
oat
passionflower
Peppermint
perilla
phosphatidylserine
phospholipids
pine bark
polygala root
pregnenolone
pyrroloquinoline disodium salt
quail egg
relora® (proprietary)
Rhodiola
rose oil
saffron
sceletium
black ginger
skullcap
spearmint leaf
spinach
Valerian root
velvet bean
vitamin B12
vitamin B6
Mulberry
whole adrenal glandular
Zinc
sarsaparilla
suma
jiaogulan
catnip
cardamom
anise
Fumaria parviflora
bee pollen
lingzhi
kanna
silk tree
oriental arborvitae
anemarrhena asphodeloides
St. John's Wort
Yerba mate
noni
Wood betony
biota seed
goji berry
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
star of Bethlehem
7,8-Dihydroxyflavone
Aralia
arjuna
Akebia
antler
Agastache
Agrimony
apigenin
Antrodia camphorata
Arginine aspartate
Albizia
Anserina
Agmatine
Agarwood
Alpha lactalbumin
Algal protein
betony
Baikal Skullcap
Black spruce
baccosides
Bacopin
baicalein
Basidiomycota
banyan
brahmi
Bacopa
Buddha\'s hand
borage
banana
Bifidobacteria
Bupleurum
bacoside
baicalin
bird\'s nest
Centella triterpenes
Monkey flower
Clary sage
Chinese mountain ant
Codonopsis
coriander
Clerodendrum phlomidis
Chinese fleeceflower
chuchuhuasi
Cymbopogon martini
Calea zacatechichi
Centella asiatica
coca
chocolate
Capitate Valerian
corktree
catuaba
C-phycocyanin
cypress
cowslip
calamus
cherimoya
Convolvulus prostratus
Corydalis
Convolvulus pluricaulis
Celastrus
Canscora
dismutase
dodeca-2E, 4E-dienoic acid isobutylamide
dibenzo-alpha pyrones
devil\'s club
date
dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
Eplotab
Erythrina
emblicanin
Eurycoma Longifolia
fo-ti
fragrant rosewood
Ficus religiosa
fish
frankincense
flavones
goldthread
Gelsemium
Ginsenosides
Griffonia simplicifolia
gum
galactooligosaccharides
Glycine
gastrodin
Honokiol
Hemidesmus
Homalomena
Hypericum
hericium mushroom
honeybush
isoliquiritigenin
Japanese kadsura
jasmine
jujubosides
Jatamansi
kavalactones
Kukicha
kola nut
kuding tea
Lycium
lemon balm
Lactucarium
linden
Lactococcus rhamnosus
Lactucopicrin
limonene
longan
Lavandin
lotus
Leptadenia
Large-leaved linden
lupulinum
lactalbumin
Mentha haplocalyx
macamides
mandarin
maral root
mangiferin
Myrcene
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Marjoram
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Methylxanthine
Mimosa
Meadow sage
Mate
magnolol
Mulungu
macaenes
Mesembrine
Nardostachys
Night jessamine
Nymphaea caerulea
oolong tea
orchid
Oxindole alkaloids
pyrroloquinoline quinone
Piper chaba
Patchouli oil
Pepper Bark Tree
Pentatropis capensis
Passionfruit
poppy
Pistachio
Polygala
Purple Monkeyflower
rosavins
Rosabin
Rauvolfia
Rehmannia
rose
Rooibos
Speedwell
Sumbul
Spikenard
Scleranthus annus
Salidroside
Safed musli
Sarivan
Shankhpushpi
Sweet Woodruff
Schisandrins
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Semecarpus anacardium
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Schizandrol A
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Sandy Everlasting
Shilajit
Safranal
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Traveler's Joy
Trichilia catigua
Taxillus chinensis
Trichopus zeylanicus
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Tagara
Tetrahydropalmatine
Uncaria
Vetiver
Valerenic acid
Vine tea
Vitexin
Viburnum
Verbena
Vanilla
Withanolides
Wogonin
Xanthine
Xanthophyll
Xylaria nigripes
Xanthone
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Yellow-Fruit Nightshade
Yumberry
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Ylang ylang

Products containing Vitamin B6 (Pyridoxine HCl)

We currently have no products on Vitabase that contain this ingredient.