Evidence supporting the use of: 7,8-Dihydroxyflavone
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7,8-Dihydroxyflavone (7,8-DHF) is a synthetic flavonoid that acts as a selective agonist of the TrkB receptor, which is the main receptor for brain-derived neurotrophic factor (BDNF). BDNF signaling has a critical role in neuronal survival, neuroplasticity, and recovery after brain injury, making 7,8-DHF an interesting candidate for stroke-related research. Preclinical studies in animal models of ischemic stroke have demonstrated that administration of 7,8-DHF can reduce neuronal death, decrease infarct volume, and improve functional recovery. These effects are thought to arise from its neuroprotective properties, including the activation of pro-survival signaling pathways (e.g., PI3K/Akt and MAPK/ERK) and reduction of oxidative stress and inflammation. For example, a 2014 study published in Brain Research showed that 7,8-DHF administration after stroke in mice improved behavioral outcomes and reduced tissue damage. However, despite encouraging results in animal studies, there is currently no substantial evidence from human clinical trials supporting the use of 7,8-DHF for stroke treatment or recovery. Thus, while the rationale for its use is grounded in modern scientific investigation, the evidence is still preliminary and limited to preclinical models.

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