Evidence supporting the use of: DHA
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid predominantly found in fish oils. Scientific interest in DHA for stroke derives from its anti-inflammatory, neuroprotective, and membrane-stabilizing properties. In preclinical studies using animal models of ischemic stroke, DHA administration—especially when given soon after the event—has been shown to reduce infarct size, limit neuronal cell death, and improve functional recovery. Proposed mechanisms include modulation of neuroinflammation, reduction of oxidative stress, and support of neuronal membrane integrity. Some animal studies also suggest DHA may promote neurogenesis and synaptic plasticity after stroke.

However, translation to human clinical efficacy is limited. Observational studies indicate that higher dietary intake of DHA (usually via fish consumption) is associated with a reduced risk of stroke incidence, but these do not establish causality or direct therapeutic benefit post-stroke. There are few randomized controlled trials (RCTs) specifically evaluating DHA supplementation as an acute or adjunctive stroke therapy in humans, and results so far are inconclusive or negative. Most human trials have focused on primary prevention or other cardiovascular outcomes rather than acute stroke treatment.

In summary, while there is a substantial body of preclinical evidence supporting the neuroprotective potential of DHA in stroke, high-quality clinical trial data in humans are lacking. Therefore, while the use of DHA for stroke is scientifically motivated, the current evidence supporting its use as a treatment is weak (rated 2/5).

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