Evidence supporting the use of: Salvianolic acid
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis of Salvianolic Acid Use in Stroke

Salvianolic acid is a major bioactive component extracted from Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. Its use in the context of stroke is primarily supported by preclinical scientific research, rather than robust clinical evidence.

Experimental studies, mainly in vitro and in animal models, have shown that salvianolic acid exhibits significant antioxidant, anti-inflammatory, and neuroprotective properties. In rodent models of ischemic stroke, it has been reported to reduce infarct size, suppress neuronal apoptosis, improve microcirculation, and attenuate blood-brain barrier damage. These effects are thought to be mediated through scavenging free radicals, inhibiting inflammatory cytokines, and modulating signaling pathways such as MAPK and NF-κB.

Despite these promising preclinical findings, high-quality human clinical trials are lacking. Some small-scale clinical studies and meta-analyses (usually involving Salvia miltiorrhiza extracts rather than isolated salvianolic acid) suggest potential benefit as an adjunct therapy in ischemic stroke recovery, but results are inconclusive and often limited by methodological weaknesses.

In summary, while there is substantial scientific interest and promising animal data for salvianolic acid in stroke models, direct clinical evidence remains insufficient. Thus, its use for stroke is supported by preclinical scientific validation rather than established clinical practice.

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