Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide Dismutase (SOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide, mitigating oxidative stress in cells. In the context of stroke, particularly ischemic stroke, a burst of reactive oxygen species (ROS) occurs during reperfusion, contributing to neuronal injury. Experimental and preclinical studies have demonstrated that administration of SOD or SOD mimetics can reduce infarct size and improve neurological outcomes in animal models of stroke. However, clinical evidence in humans remains limited and inconsistent. Some early-phase clinical trials have explored SOD (often as bovine-derived SOD or SOD mimetics), but results have not provided strong or consistent evidence of benefit. Challenges include SOD's poor ability to cross the blood-brain barrier and rapid degradation in the bloodstream. Therefore, while there is a mechanistic rationale and supportive animal data, high-quality human trials are lacking, and SOD is not an established or routinely recommended therapy for stroke in clinical practice. Its use in this context is best described as experimental, with scientific interest but only modest supporting evidence to date.

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