Evidence supporting the use of: Arginine
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine is a semi-essential amino acid that plays a role in several physiological processes, primarily related to nitric oxide production, immune function, and wound healing. Its relevance to the Structural System—which encompasses bones, joints, cartilage, and connective tissue—is supported by some scientific research, although the evidence is not robust or conclusive.

Arginine serves as a precursor for the synthesis of nitric oxide, a molecule that promotes vasodilation and may indirectly support tissue repair by increasing blood flow. Some studies suggest that arginine supplementation can enhance collagen synthesis and wound healing, which are important for the maintenance and repair of connective tissues. For example, clinical trials in surgical patients have shown that arginine-enriched formulas may improve wound healing outcomes. There is also experimental evidence suggesting arginine may stimulate the release of growth hormone and insulin-like growth factor-1 (IGF-1), which have anabolic effects that could theoretically support bone and muscle health.

However, direct evidence supporting arginine supplementation specifically for strengthening or protecting the structural system (bones, joints, cartilage) in healthy individuals is limited. Most research focuses on wound healing or recovery from injury rather than ongoing structural maintenance. Thus, while there is some scientific rationale and preliminary evidence, the overall strength of evidence for arginine's use in supporting the structural system is modest.

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