Evidence supporting the use of: Chondroitin
For the body system: Structural System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chondroitin is commonly used to support the structural system, particularly joint health. There is a scientific basis for its use, primarily in the context of osteoarthritis. Chondroitin is a natural component of cartilage, the connective tissue that cushions joints. Several clinical studies and meta-analyses have investigated the efficacy of chondroitin sulfate, often in combination with glucosamine, for reducing symptoms of osteoarthritis such as joint pain and functional impairment.

The evidence is mixed. Some studies and systematic reviews suggest a modest benefit for pain reduction and improved joint function, while others find little to no significant difference compared to placebo. The 2015 Cochrane Review concluded that chondroitin may improve pain slightly more than placebo and improve quality of life, but the effects are likely small and the clinical relevance is debated. Guidelines from organizations such as the American College of Rheumatology do not strongly recommend chondroitin due to variability in the evidence.

Despite this, chondroitin remains widely used, and its safety profile is generally considered good. Its use is supported by a moderate body of scientific evidence, especially for individuals with mild to moderate osteoarthritis, although it is not universally endorsed by clinical guidelines. There is little traditional or historical use outside of scientific research and modern supplementation.

More about chondroitin
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Other body systems supported by chondroitin

Joints
Skeletal System (Bones)
Spinal Disks
Structural System