Evidence supporting the use of: Chondroitin Sulfate
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chondroitin sulfate is a naturally occurring glycosaminoglycan found in connective tissues, especially cartilage. It is commonly used as a dietary supplement to support the Structural System, particularly joint health. A substantial body of research, including randomized controlled trials and systematic reviews, has investigated its efficacy in conditions such as osteoarthritis. Some studies suggest that chondroitin sulfate supplementation may help reduce joint pain, improve function, and slow the progression of cartilage loss, likely due to its role in maintaining cartilage integrity and inhibiting cartilage-degrading enzymes.

However, the quality and outcomes of these studies have been mixed. Some meta-analyses report modest benefits for pain and functional improvement, while others find little to no clinically important effect compared to placebo. Major health authorities, such as the American College of Rheumatology, consider the evidence for chondroitin to be moderate but not definitive, and do not universally recommend its use. Nonetheless, the ingredient remains widely used, especially in combination with glucosamine, because of its favorable safety profile and potential benefit for some individuals.

In summary, the use of chondroitin sulfate to support the Structural System is based on both biological plausibility and moderate scientific evidence, though consensus on its efficacy is not unanimous.

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Other body systems supported by Chondroitin Sulfate

Joints
Skeletal System (Bones)
Spinal Disks
Structural System

Products containing Chondroitin Sulfate

We currently have no products on Vitabase that contain this ingredient.