Evidence supporting the use of: Creatine-leucine
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine and leucine are both well-established supplements in sports nutrition, particularly for their roles in supporting the structural system, which includes muscles and bones. Creatine is widely recognized for its ability to increase muscle mass, strength, and exercise performance by replenishing adenosine triphosphate (ATP) stores in muscle cells, thus enhancing energy availability during high-intensity activities. Numerous randomized controlled trials and meta-analyses confirm creatine’s efficacy in promoting muscle hypertrophy, strength, and recovery.

Leucine, an essential branched-chain amino acid (BCAA), acts as a key regulator of muscle protein synthesis via the mTOR pathway. Supplementation with leucine has been shown to stimulate muscle growth, reduce muscle breakdown, and support recovery, especially when combined with resistance exercise.

While both ingredients are individually validated for supporting muscle structure and function, research on combination “creatine-leucine” supplementation is more limited. However, some studies suggest potential synergistic effects, as both support distinct but complementary aspects of muscle anabolism and energy metabolism. For the structural system (skeletal muscle), their combined use is grounded in scientific evidence, though most data pertain to their separate administration. There is less evidence for direct effects on bone, but some emerging research suggests creatine and leucine may indirectly support bone health by enhancing muscle strength and physical activity.

In summary, creatine and leucine are scientifically validated for supporting the structural system, primarily through their effects on muscle mass, strength, and recovery.

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Other body systems supported by Creatine-leucine

Brain
Muscles
Structural System

Products containing Creatine-leucine

We currently have no products on Vitabase that contain this ingredient.