Evidence supporting the use of: Glucosamine
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glucosamine is widely used as a dietary supplement to support joint health, which is a key component of the structural system (bones, joints, cartilage). The justification for its use is primarily based on scientific studies, although results are mixed. Glucosamine is a naturally occurring amino sugar found in cartilage, and supplementation is believed to help maintain or rebuild cartilage, especially in people with osteoarthritis.

Several randomized controlled trials and meta-analyses have investigated glucosamine's effects on osteoarthritis, particularly of the knee. Some studies suggest modest benefits in reducing pain and improving joint function, while others find little to no effect compared to placebo. The largest and most rigorous studies, such as the GAIT trial (Glucosamine/chondroitin Arthritis Intervention Trial), generally show no significant difference from placebo, though some subgroups (e.g., those with moderate-to-severe pain) may benefit.

The European League Against Rheumatism and Osteoarthritis Research Society International acknowledge that glucosamine sulfate (but not hydrochloride) may provide symptom relief for some individuals with knee osteoarthritis. However, authoritative bodies such as the American College of Rheumatology do not recommend its routine use due to insufficient evidence for meaningful benefit.

In summary, there is scientific investigation and a plausible biological rationale for glucosamine supporting joint health within the structural system, but the quality of evidence is moderate and somewhat inconsistent, leading to a rating of 3 out of 5.

More about glucosamine
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Other body systems supported by glucosamine

Joints
Structural System