Evidence supporting the use of: Glucosamine (mixed type)
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glucosamine is commonly used as a dietary supplement to support the structural system, particularly joint health. The structural system includes bones, cartilage, ligaments, and other connective tissues. Glucosamine is a naturally occurring amino sugar found in cartilage and is thought to play a role in building and maintaining cartilage integrity. Scientific research has primarily focused on its effectiveness in managing symptoms of osteoarthritis, particularly in the knee. Several randomized controlled trials and meta-analyses have shown that glucosamine (often as glucosamine sulfate) may provide modest pain relief and improve joint function in people with mild to moderate osteoarthritis. However, not all studies agree, and some have found little to no benefit compared to placebo.

Most evidence supports the use of glucosamine for symptom management rather than structural regeneration or disease modification. The "mixed type" (a combination of glucosamine sulfate and glucosamine hydrochloride) is less well studied than glucosamine sulfate alone. Guidelines from organizations such as the American College of Rheumatology are cautious, often stating that glucosamine may be tried for osteoarthritis, but evidence is not strong enough for widespread recommendation. Overall, scientific validation for glucosamine's role in supporting the structural system is moderate, with the most support for symptom relief in osteoarthritis rather than broad structural support.

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Other body systems supported by Glucosamine (mixed type)

Joints
Structural System

Products containing Glucosamine (mixed type)

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