Evidence supporting the use of: Glucosamine Sulfate
For the body system: Structural System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glucosamine sulfate is commonly used as a dietary supplement to support the structural system, particularly for joint health. Scientific evidence suggests that glucosamine sulfate may help reduce symptoms associated with osteoarthritis, a degenerative joint condition that affects the cartilage. Several randomized controlled trials and meta-analyses have evaluated its efficacy, with mixed but generally positive results for mild to moderate osteoarthritis, particularly of the knee. Some studies show modest improvements in pain and function compared to placebo, while others find no significant difference.

Glucosamine is a naturally occurring amino sugar found in cartilage. The sulfate form is considered superior to other forms (such as glucosamine hydrochloride) in terms of clinical benefit, though the difference is not dramatic. Its proposed mechanism involves supporting the synthesis of glycosaminoglycans, which are essential components of joint cartilage and synovial fluid.

While glucosamine sulfate is not universally recommended by all clinical guidelines, organizations such as the European League Against Rheumatism (EULAR) and the Osteoarthritis Research Society International (OARSI) recognize it as a symptomatic slow-acting drug for osteoarthritis (SYSADOA). However, the American College of Rheumatology does not currently recommend it, reflecting ongoing debate about its clinical significance.

In summary, there is moderate scientific evidence supporting the use of glucosamine sulfate for structural system support, primarily in the context of joint health and osteoarthritis symptom management.

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Other body systems supported by Glucosamine Sulfate

Joints
Structural System

Products containing Glucosamine Sulfate

We currently have no products on Vitabase that contain this ingredient.