Evidence supporting the use of: Glycine
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycine is an amino acid that plays a crucial role in the synthesis of proteins, collagen, and other macromolecules critical for the structural system, including bones, tendons, ligaments, and skin. Scientific evidence supports glycine’s involvement in collagen production, as approximately one-third of collagen’s amino acid content is glycine. Studies have shown that glycine supplementation can enhance collagen synthesis, which directly impacts the strength and flexibility of connective tissues. Several animal and in vitro studies demonstrate that glycine is necessary for proper bone development and joint health. Human clinical trials are more limited but suggest potential benefits: for example, glycine supplementation has been associated with improved skin elasticity and reduced joint pain in small studies. However, while the mechanistic role of glycine in collagen and connective tissue health is well established, direct robust clinical evidence for glycine supplementation specifically to support the structural system in healthy humans is still emerging. Thus, the evidence is moderate (rated 3/5), grounded in well-understood biochemistry and some preliminary clinical findings, but lacks large-scale, long-term human studies conclusively demonstrating structural system benefits from supplemental glycine.

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Products containing Glycine

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