Evidence supporting the use of: Omega-3 fatty acids
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Omega-3 fatty acids, primarily EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are well-studied for their effects on various body systems, including the structural system—particularly bone and joint health. Several observational and interventional studies suggest that omega-3s may play a role in supporting bone density and joint function. The proposed mechanisms include modulation of inflammatory pathways, enhancement of calcium absorption, and influence on bone metabolism by affecting osteoblast and osteoclast activity. Some randomized controlled trials have shown that supplementation with omega-3s can reduce markers of bone resorption and inflammation in populations at risk for osteoporosis and rheumatoid arthritis. However, results are mixed; not all studies demonstrate significant improvements in bone mineral density or clinical endpoints such as fracture reduction.

For joint health, omega-3 fatty acids have a clearer benefit, particularly in reducing symptoms of rheumatoid arthritis and possibly osteoarthritis, due to their anti-inflammatory properties. Major health organizations acknowledge their role in supporting joint function, though evidence for direct effects on bone structure is less robust. In summary, there is moderate scientific evidence supporting the use of omega-3 fatty acids for aspects of the structural system, especially joint health, but less so for significant improvements in overall bone strength or structure.

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